| Foreword by Professor Sir Magdi Yacoub | ||
| Identity | ||
| Teaching | ||
| Funding | ||
| History | ||
| Management Structure | ||
| How to reach us | ||
| Seminars | ||
| Student Presentation Day 2006 | ||
| Bioengineering the Heart - Royal Society | ||
| New Collaboration with EMBL | ||
Allen S, Dashwood M, Morrison K, & Yacoub M (1998). Differential leukotriene constrictor responses in human atherosclerotic coronary arteries. Circulation 97 , 2406-2413. Allen S, Khan S, Al Mohanna F, Batten P, & Yacoub M (1998). Native low density lipoprotein-induced calcium transients trigger VCAM-1 and E-selectin expression in cultured human vascular endothelial cells. J Clin Invest 101 , 1064-1075. Allen S, Khan S, Tam S, Koschinsky M, Taylor P, & Yacoub M (1998). Expression of adhesion molecules by lp(a): a potential novel mechanism for its atherogenicity. FASEB J 12 , 1765-1776. Amrani M, Smolenski RT, Goodwin AT, Gray CC, Jayakumar J, Jagodzinski P, & Yacoub MH (1998). Differences in nucleotide metabolism and mechanical recovery after cardioplegic arrest of the heart at different age. Adv Exp Med Biol 431 , 377-379. Amrani M, Latif N, Morrison K, Gray CC, Jayakumar J, Corbett J, Goodwin AT, Dunn MJ, & Yacoub MH (1998). Relative induction of heat shock protein in coronary endothelial cells and cardiomyocytes: implications for myocardial protection. J Thorac Cardiovasc Surg 115 , 200-209. Bach DS, David T, Yacoub M, Pepper J, Goldman B, Wood J, Verrier E, Petracek M, Aldrete V, Rosenbloom M, Azar H, & Rakowski H (1998). Hemodynamics and left ventricular mass regression following implantation of the Toronto SPV stentless porcine valve. Am J Cardiol 82 , 1214-1219. Beesley CE, Child AH, & Yacoub MH (1998). The identification of five novel mutations in the lysosomal acid a-(1-4) glucosidase gene from patients with glycogen storage disease type II. Mutations in brief no. 134. Online. Hum Mutat 11 , 413. Belvisi MG, Saunders M, Yacoub M, & Mitchell JA (1998). Expression of cyclo-oxygenase-2 in human airway smooth muscle is associated with profound reductions in cell growth. Br J Pharmacol 125 , 1102-1108. Boateng SY, Seymour AM, Bhutta NS, Dunn MJ, Yacoub MH, & Boheler KR (1998). Sub-antihypertensive doses of ramipril normalize sarcoplasmic reticulum calcium ATPase expression and function following cardiac hypertrophy in rats. J Mol Cell Cardiol 30 , 2683-2694. Borland JA, Chester AH, Crabbe S, Parkerson JB, Catravas JD, & Yacoub MH (1998). Differential action of angiotensin II and activity of angiotensin-converting enzyme in human bypass grafts. J Thorac Cardiovasc Surg 116 , 206-212. Borland JA, Chester AH, Morrison KA, & Yacoub MH (1998). Alternative pathways of angiotensin II production in the human saphenous vein. Br J Pharmacol 125 , 423-428. Buckley MG, Yacoub MH, & Singer DR (1998). Investigation of the plasma concentrations and circulating forms of BNP and ANP in orthotopic cardiac transplant recipients. J Hum Hypertens 12 , 825-826. Buckley MG, Marcus NJ, Yacoub MH, & Singer DR (1998). Prolonged stability of brain natriuretic peptide: importance for non-invasive assessment of cardiac function in clinical practice. Clin Sci (Lond) 95 , 235-239. Burton PB, Yacoub MH, & Barton PJ (1998). Rapamycin (sirolimus) inhibits heart cell growth in vitro. Pediatr Cardiol 19 , 468-470. Chester AH, Buttery LD, Borland JA, Springall DR, Rothery S, Severs NJ, Polak JM, & Yacoub MH (1998). Structural, biochemical and functional effects of distending pressure in the human saphenous vein: implications for bypass grafting. Coron Artery Dis 9 , 143-151. Chester AH, Borland JA, Morrison KJ, Amrani M, Thom SM, & Yacoub MH (1998). Reactivity of small intramyocardial arteries from atherosclerotic and non-atherosclerotic human hearts. J Vasc Res 35 , 170-178. Chester AH, Birks EJ, & Yacoub MH (1998). Role of nitric oxide following cardiac transplantation. J Hum Hypertens 12 , 833-837. Chester AH, Marchbank AJ, Borland JA, Yacoub MH, & Taggart DP (1998). Comparison of the morphologic and vascular reactivity of the proximal and distal radial artery. Ann Thorac Surg 66 , 1972-1976. Chester AH, Amrani M, & Borland JA (1998). Vascular biology of the radial artery. Curr Opin Cardiol 13 , 447-452. Chester AH, Morrison KJ, & Yacoub MH (1998). Expression of vascular adhesion molecules in saphenous vein coronary bypass grafts. Ann Thorac Surg 65 , 1685-1689. Chester AH, Borland JA, Buttery LD, Mitchell JA, Cunningham DA, Hafizi S, Hoare GS, Springall DR, Polak JM, & Yacoub MH (1998). Induction of nitric oxide synthase in human vascular smooth muscle: interactions between proinflammatory cytokines. Cardiovasc Res 38 , 814-821. Christer JF, Yacoub MH, & Brand NJ (1998). A versatile method for unidirectional cloning of oligonucleotide cassettes: application to creating concatamerized transcription factor binding sites. Anal Biochem 256 , 142-145. Corbett JM, Why HJ, Wheeler CH, Richardson PJ, Archard LC, Yacoub MH, & Dunn MJ (1998). Cardiac protein abnormalities in dilated cardiomyopathy detected by two-dimensional polyacrylamide gel electrophoresis. Electrophoresis 19 , 2031-2042. Cunningham DA, Crisp SJ, Barbir M, Lazem F, Dunn MJ, & Yacoub MH (1998). Donor ACE gene polymorphism: a genetic risk factor for accelerated coronary sclerosis following cardiac transplantation. European Heart Journal 19 , 319-325. El Oakley RM, Brand NJ, Burton PB, McMullen MC, Adams GB, Poznansky MC, Barton PJ, & Yacoub MH (1998). Efficiency of a high-titer retroviral vector for gene transfer into skeletal myoblasts. J Thorac Cardiovasc Surg 115 , 1-8. Farza H, Townsend PJ, Carrier L, Barton PJ, Mesnard L, Bahrend E, Forissier JF, Fiszman M, Yacoub MH, & Schwartz K (1998). Genomic organisation, alternative splicing and polymorphisms of the human cardiac troponin T gene. J Mol Cell Cardiol 30 , 1247-1253. Fisher AR, Jones P, Barlow P, Kennington S, Saville S, Farrimond J, & Yacoub M (1998). The influence of mannitol on renal function during and after open-heart surgery. Perfusion 13 , 181-186. Goodwin AT, Amrani M, Gray CC, Jayakumar J, & Yacoub MH (1998). Role of endogenous endothelin in the regulation of basal coronary tone in the rat. J Physiol 511 ( Pt 2) , 549-557. Gray CC, Smolenski RT, Amrani M, Goodwin AT, Jayakumar J, Jagodzinski P, & Yacoub MH (1998). Influence of ageing on functional recovery and guanine nucleotide levels of the heart following cold cardioplegic arrest. Eur J Cardiothorac Surg 13 , 475-480. Habib SB, Congleton J, Carr D, Partridge J, Corrin B, Geddes DM, Banner N, Yacoub M, & Burke M (1998). Recurrence of recipient Langerhans' cell histiocytosis following bilateral lung transplantation. Thorax 53 , 323-325. Hafizi S, Chester AH, Allen SP, Morgan K, & Yacoub MH (1998). Growth response of human coronary smooth muscle cells to angiotensin II and influence of angiotensin AT1 receptor blockade. Coron Artery Dis 9 , 167-175. Hafizi S, Wharton J, Morgan K, Allen SP, Chester AH, Catravas JD, Polak JM, & Yacoub MH (1998). Expression of functional angiotensin-converting enzyme and AT1 receptors in cultured human cardiac fibroblasts. Circulation 98 , 2553-2559. Hafizi S, Nobin R, Allen SP, Chester AH, & Yacoub MH (1998). Contrasting effects of platelet-derived growth factor (PDGF) isomers on mitogenesis, contraction and intracellular calcium concentration in human vascular smooth muscle. Acta Physiol Scand 164 , 191-199. Heinke MY, Wheeler CH, Chang D, Einstein R, Drake-Holland A, Dunn MJ, & Dos Remedios CG (1998). Protein changes observed in pacing-induced heart failure using two-dimensional electrophoresis. Electrophoresis 19 , 2021-2030. Hornick PI, Mason PD, Yacoub MH, Rose ML, Batchelor R, & Lechler RI (1998). Assessment of the contribution that direct allorecognition makes to the progression of chronic cardiac transplant rejection in humans. Circulation 97 , 1257-1263. Hunt BJ, Parratt RN, Segal HC, Sheikh S, Kallis P, & Yacoub M (1998). Activation of coagulation and fibrinolysis during cardiothoracic operations. Ann Thorac Surg 65 , 712-718. Jayakumar J, Smolenski RT, Gray CC, Goodwin AT, Kalsi K, Amrani M, & Yacoub MH (1998). Influence of heat stress on myocardial metabolism and functional recovery after cardioplegic arrest: a 31P N.M.R study. Eur J Cardiothorac Surg 13 , 467-474. Johnson DL, Sloan C, O'Halloran A, & Yacoub MH (1998). Effect of antibiotic pretreatment on immunogenicity of human heart valves and component cells. Ann Thorac Surg 66 , S221-S224. Jurcevic S, Dunn MJ, Crisp S, Busing K, Rinaldi M, Pellegrini C, Yacoub MH, Vigano M, Banner NL, & Rose ML (1998). A new enzyme-linked immunosorbent assay to measure anti-endothelial antibodies after cardiac transplantation demonstrates greater inhibition of antibody formation by tacrolimus compared with cyclosporine. Transplantation 65 , 1197-1202. Kalsi KK, Smolenski RT, & Yacoub MH (1998). Effects of nucleoside transport inhibitors and adenine/ribose supply on ATP concentration and adenosine production in cardiac myocytes. Mol Cell Biochem 180 , 193-199. Kalsi KK, Smolenski RT, Pritchard RD, Khaghani A, Seymour AM, & Yacoub MH (1998). Effects of dipyridamole and adenine/ribose on ATP concentration and adenosine production in cardiac myocytes. Adv Exp Med Biol 431 , 781-784. Kalsi KK, Smolenski RT, & Yacoub MH (1998). Effects of nucleoside transport inhibitors and adenine/ribose on ATP concentration and adenosine production in cardiac myocytes. Adv Exp Med Biol 431 , 95-98. Koban MU, Moorman AF, Holtz J, Yacoub MH, & Boheler KR (1998). Expressional analysis of the cardiac Na-Ca exchanger in rat development and senescence. Cardiovasc Res 37 , 405-423. Lam KM, Oldenburg N, Khan MA, Gaylore V, Mikhail GW, Strouhal PD, Middeldorp JM, Banner N, & Yacoub M (1998). Significance of reverse transcription polymerase chain reaction in the detection of human cytomegalovirus gene transcripts in thoracic organ transplant recipients. J Heart Lung Transplant 17 , 555-565. Lidington EA, McCormack AM, Yacoub MH, & Rose ML (1998). The effects of monocytes on the transendothelial migration of T lymphocytes. Immunology 94 , 221-227. Marcus N, Khaghani A, Burke M, Yacoub M, & Banner N (1998). Medium-term outcome of tacrolimus immunosuppression following rejection or graft dysfunction in heart transplant patients. Transplant Proc 30 , 1134-1135. Marczin N, Riedel B, Royston D, & Yacoub M (1998). Exhaled nitric oxide and pulmonary response to iloprost in systemic sclerosis. Lancet 352 , 405-406. Marlewski M, Smolenski RT, Laurence A, Simmonds HA, & Swierczynski J (1998). Evaluation of adenine concentration in plasma of patients with renal failure using improved ultrafiltration technique. Adv Exp Med Biol 431 , 785-787. Mason NA, Springall DR, Pomerance A, Evans TJ, Yacoub MH, & Polak JM (1998). Expression of inducible nitric oxide synthase and formation of peroxynitrite in posttransplant obliterative bronchiolitis. J Heart Lung Transplant 17 , 710-714. Mason NA, Springall DR, Burke M, Pollock J, Mikhail G, Yacoub MH, & Polak JM (1998). High expression of endothelial nitric oxide synthase in plexiform lesions of pulmonary hypertension. J Pathol 185 , 313-318. Meng QH, Springall DR, Bishop AE, Morgan K, Evans TJ, Habib S, Gruenert DC, Gyi KM, Hodson ME, Yacoub MH, & Polak JM (1998). Lack of inducible nitric oxide synthase in bronchial epithelium: a possible mechanism of susceptibility to infection in cystic fibrosis. J Pathol 184 , 323-331. Mikhail G, Eadon H, Leaver N, Khaghani A, Yacoub M, & Banner N (1998). Comparison of neoral and sandimmun cyclosporines for de novo lung transplantation in cystic fibrosis patients. Transplant Proc 30 , 1510-1511. Mikhail G, Chester AH, Gibbs JS, Borland JA, Banner NR, & Yacoub MH (1998). Role of vasoactive mediators in primary and secondary pulmonary hypertension. Am J Cardiol 82 , 254-255. Morrell NW, Upton PD, Higham MA, Yacoub MH, Polak JM, & Wharton J (1998). Angiotensin II stimulates proliferation of human pulmonary artery smooth muscle cells via the AT1 receptor. Chest 114 , 90S-91S. Norman DA, Yacoub MH, & Barton PJ (1998). Nuclear factor NF-kappa B in myocardium: developmental expression of subunits and activation by interleukin-1 beta in cardiac myocytes in vitro. Cardiovasc Res 39 , 434-441. Novick RJ, Stitt LW, Al Kattan K, Klepetko W, Schafers HJ, Duchatelle JP, Khaghani A, Hardesty RL, Patterson GA, & Yacoub MH (1998). Pulmonary retransplantation: predictors of graft function and survival in 230 patients. Pulmonary Retransplant Registry. Ann Thorac Surg 65 , 227-234. Pate MA, Chester AH, Brown TJ, Roach AG, & Yacoub MH (1998). Atypical antagonism observed with BQ-123 in human saphenous vein. J Cardiovasc Pharmacol 31 Suppl 1 , S172-S174. Polak J, Oakley CM, Yacoub M, Mikhail G, & Taylor-Robinson SD (1998). Primary pulmonary hypertension: pathologist as patient. J R Coll Physicians Lond 32 , 225-230. Reichart B, Meiser B, Vigano M, Rinaldi M, Martinelli L, Yacoub M, Banner NR, Gandjbakhch I, Dorent R, Hetzer R, & Hummel M (1998). European Multicenter Tacrolimus (FK506) Heart Pilot Study: one-year results--European Tacrolimus Multicenter Heart Study Group. J Heart Lung Transplant 17 , 775-781. Rose ML (1998). Endothelial cells as antigen-presenting cells: role in human transplant rejection. Cell Mol Life Sci 54 , 965-978. Ruckemann K, Laurence A, Fairbanks LD, Richards D, Smolenski RT, Hawrylowicz C, Bofill M, & Simmonds HA (1998). Biochemical basis for the impaired immune response in chronic renal failure? Adv Exp Med Biol 431 , 559-563. Segal H, Sheikh S, Kallis P, Cottam S, Beard C, Potter D, Townsend E, Bidstrup BP, Yacoub M, & Hunt BJ (1998). Complement activation during major surgery: the effect of extracorporeal circuits and high-dose aprotinin. J Cardiothorac Vasc Anesth 12 , 542-547. Singer DR & Yacoub MH (1998). Introduction to 'hypertension in transplant recipients'. J Hum Hypertens 12 , 811. Smith JD, Yacoub MH, & Rose ML (1998). Endothelial cell activation by sera containing HLA antibodies is mediated by interleukin-1. Transplantation 66 , 1229-1237. Smith JD, Hornick PI, Rasmi N, Rose ML, & Yacoub MH (1998). Effect of HLA mismatching and antibody status on "homovital" aortic valve homograft performance. Ann Thorac Surg 66 , S212-S215. Smolenski RT, Kalsi K, Zych M, Kochan Z, & Yacoub MH (1998). Effects of adenine/ribose supply on adenosine production and ATP concentration in adenosine kinase inhibited cardiac cells. Adv Exp Med Biol 431 , 385-388. Smolenski RT, Jayakumar J, Seymour AM, & Yacoub MH (1998). The effects of nucleotide pool on purine production in the postischemic heart. Adv Exp Med Biol 431 , 271-274. Smolenski RT, Jayakumar J, Seymour AM, & Yacoub MH (1998). High-energy phosphate changes in the normal and hypertrophied heart during cardioplegic arrest and ischemia. Adv Exp Med Biol 431 , 283-286. Smolenski RT, Jayakumar J, Seymour AM, & Yacoub MH (1998). Energy metabolism and mechanical recovery after cardioplegia in moderately hypertrophied rats. Mol Cell Biochem 180 , 137-143. Smolenski RT, Kalsi KK, Zych M, Kochan Z, & Yacoub MH (1998). Adenine/ribose supply increases adenosine production and protects ATP pool in adenosine kinase-inhibited cardiac cells. J Mol Cell Cardiol 30 , 673-683. Smolenski RT, Gray C, Jayakumar J, Amrani M, & Yacoub MH (1998). Nucleotide metabolism in the heart subjected to heat stress. Adv Exp Med Biol 431 , 373-376. Taylor-Robinson D, Ong G, Thomas BJ, Rose ML, & Yacoub MH (1998). Chlamydia pneumoniae in vascular tissues from heart-transplant donors. Lancet 351 , 1255. Walker S, Habib S, Thompson D, Khaghani A, Yacoub M, & Banner N (1998). Risks and benefits of withdrawing cyclosporine from the long-term immunosuppression regimen of heart and heart-lung transplant recipients. Transplant Proc 30 , 1149-1151. Walker S, Mikhail G, Banner N, Partridge J, Khaghani A, Burke M, & Yacoub M (1998). Medium term results of lung transplantation for end stage pulmonary sarcoidosis. Thorax 53 , 281-284. Walker S, Habib S, Rose M, Yacoub M, & Banner N (1998). Clinical use and bioavailability of tacrolimus in heart-lung and double lung transplant recipients with cystic fibrosis. Transplant Proc 30 , 1519-1520. Wharton J, Morgan K, Rutherford RA, Catravas JD, Chester A, Whitehead BF, De Leval MR, Yacoub MH, & Polak JM (1998). Differential distribution of angiotensin AT2 receptors in the normal and failing human heart. J Pharmacol Exp Ther 284 , 323-336. Wilkins MR, Gasteiger E, Wheeler CH, Lindskog I, Sanchez JC, Bairoch A, Appel RD, Dunn MJ, & Hochstrasser DF (1998). Multiple parameter cross-species protein identification using MultiIdent--a world-wide web accessible tool. Electrophoresis 19 , 3199-3206. Wong K, Boheler KR, Bishop J, Petrou M, & Yacoub MH (1998). Clenbuterol induces cardiac hypertrophy with normal functional, morphological and molecular features. Cardiovasc Res 37 , 115-122. Yacoub MH, Gehle P, Chandrasekaran V, Birks EJ, Child A, & Radley-Smith R (1998). Late results of a valve-preserving operation in patients with aneurysms of the ascending aorta and root. J Thorac Cardiovasc Surg 115 , 1080-1090. Zych M, Smolenski RT, Makarewicz W, & Yacoub MH (1998). Different mechanism of myocardial nucleotide breakdown during normothermic and hypothermic ischemia. Adv Exp Med Biol 431 , 381-383. |