Publications 2000

Aklog L, Carr-White GS, Birks EJ, & Yacoub MH (2000). Pulmonary autograft versus aortic homograft for aortic valve replacement: interim results from a prospective randomized trial. J Heart Valve Dis 9 , 176-188.

Banks RE, Dunn MJ, Hochstrasser DF, Sanchez JC, Blackstock W, Pappin DJ, & Selby PJ (2000). Proteomics: new perspectives, new biomedical opportunities. Lancet 356 , 1749-1756.

Barton PJ, Mullen AJ, Cullen ME, Dhoot GK, Simon-Chazottes D, & Guenet JL (2000). Genes encoding troponin I and troponin T are organized as three paralogous pairs in the mouse genome. Mammalian Genome 11 , 926-929.

Bellenger NG, Marcus NJ, Davies C, Yacoub M, Banner NR, & Pennell DJ (2000). Left ventricular function and mass after orthotopic heart transplantation: a comparison of cardiovascular magnetic resonance with echocardiography. J Heart Lung Transplant 19 , 444-452.

Bhavsar PK, Dellow KA, Yacoub MH, Brand NJ, & Barton PJ (2000). Identification of cis-acting DNA elements required for expression of the human cardiac troponin I gene promoter. J Mol Cell Cardiol 32 , 95-108.

Birks EJ, Yacoub MH, Burton PS, Owen V, Pomerance A, O'Halloran A, Banner NR, Khaghani A, & Latif N (2000). Activation of apoptotic and inflammatory pathways in dysfunctional donor hearts. Transplantation 70 , 1498-1506.

Birks EJ, Owen VJ, Burton PB, Bishop AE, Banner NR, Khaghani A, Polak JM, & Yacoub MH (2000). Tumor necrosis factor-alpha is expressed in donor heart and predicts right ventricular failure after human heart transplantation. Circulation 102 , 326-331.

Birks EJ, Hunt D, Grieve L, Burke M, Banner NR, & Yacoub MH (2000). A prospective study of plasma nitrates following human heart transplantation-relevance to myocardial function. J Heart Lung Transplant 19 , 324-329.

Birks EJ, Burton PB, Owen V, Mullen AJ, Hunt D, Banner NR, Barton PJ, & Yacoub MH (2000). Elevated tumor necrosis factor-alpha and interleukin-6 in myocardium and serum of malfunctioning donor hearts. Circulation 102 , III352-III358.

Borland JA, Chester AH, & Yacoub MH (2000). The renin angiotensin system in bypass graft surgery. Curr Opin Cardiol 15 , 371-377.

Borland JA, Chester AH, Rooker SJ, Wharton J, Davie N, Amrani M, & Yacoub MH (2000). Expression and function of angiotensin converting enzyme, chymase, and angiotensin II in the human radial artery and internal thoracic artery. Ann Thorac Surg 70 , 2054-2063.

Boscoe MJ, Goodwin AT, Amrani M, & Yacoub MH (2000). Endothelins and the lung. Int J Biochem Cell Biol 32 , 41-62.

Buckley MG, Jenkins GH, Mitchell AG, Yacoub MH, & Singer DR (2000). Circulating C-type natriuretic peptide is increased in orthotopic cardiac transplant recipients and associated with cardiac allograft vasculopathy. Clin Sci (Lond) 99 , 467-472.

Bundy RE, Marczin N, Birks EF, Chester AH, & Yacoub MH (2000). Transplant atherosclerosis: role of phenotypic modulation of vascular smooth muscle by nitric oxide. Gen Pharmacol 34 , 73-84.

Bundy RE, Marczin N, Chester AH, & Yacoub M (2000). A redox-based mechanism for nitric oxide-induced inhibition of DNA synthesis in human vascular smooth muscle cells. Br J Pharmacol 129 , 1513-1521.

Burton PB, Owen VJ, Hafizi S, Barton PJ, Carr-White G, Koh T, De Souza A, Yacoub MH, & Pepper JR (2000). Vascular endothelial growth factor release following coronary artery bypass surgery: extracorporeal circulation versus 'beating heart' surgery. European Heart Journal 21 , 1708-1713.

Carr-White GS, Afoke A, Birks EJ, Hughes S, O'Halloran A, Glennen S, Edwards S, Eastwood M, & Yacoub MH (2000). Aortic root characteristics of human pulmonary autografts. Circulation 102 , III15-III21.

Chester AH, Amrani M, Sproson CA, & Yacoub MH (2000). Interaction between thromboxane A2 and 5-hydroxytryptamine in the radial artery compared to the internal thoracic artery. Gen Pharmacol 35 , 89-93.

Chester AH, Misfeld M, & Yacoub MH (2000). Receptor-mediated contraction of aortic valve leaflets. J Heart Valve Dis 9 , 250-254.

Chester AH & Borland JA (2000). Chymase-dependent angiotensin II formation in human blood vessels. J Hum Hypertens 14 , 373-376.

Dunn MJ (2000). Studying heart disease using the proteomic approach. Drug Discov Today 5 , 76-84.

Ensminger SM, Witzke O, Spriewald BM, Morrison K, Morris PJ, Rose ML, & Wood KJ (2000). CD8+ T cells contribute to the development of transplant arteriosclerosis despite CD154 blockade. Transplantation 69 , 2609-2612.

Ensminger SM, Spriewald BM, Witzke O, Morrison K, van Maurik A, Morris PJ, Rose ML, & Wood KJ (2000). Intragraft interleukin-4 mRNA expression after short-term CD154 blockade may trigger delayed development of transplant arteriosclerosis in the absence of CD8+ T cells. Transplantation 70 , 955-963.

Farrar MW, McDouall R, Khan S, Yacoub MH, & Allen SP (2000). Serum activation unmasks unique sensitivities to adhesion molecule expression in human coronary artery and heart microvascular endothelial cells. Microvasc Res 59 , 338-344.

Gamble SC, Dunn MJ, Wheeler CH, Joiner MC, Adu-Poku A, & Arrand JE (2000). Expression of proteins coincident with inducible radioprotection in human lung epithelial cells. Cancer Res 60 , 2146-2151.

Gray CC, Smolenski RT, Amrani M, Taylor GL, & Yacoub MH (2000). Influence of age and heat stress on cardiac function and nucleotide levels. Adv Exp Med Biol 486 , 153-157.

Gray CC, Amrani M, Smolenski RT, Taylor GL, & Yacoub MH (2000). Age dependence of heat stress mediated cardioprotection. Ann Thorac Surg 70 , 621-626.

Grocott-Mason RM, Lund O, Elwidaa H, Mazhar R, Chandrasakeran V, Mitchell AG, Ilsley C, Khaghani A, Rees A, & Yacoub M (2000). Long-term results after aortic valve replacement in patients with congestive heart failure. Homografts vs prosthetic valves. European Heart Journal 21 , 1698-1707.

Hafizi S, Taylor PM, Chester AH, Allen SP, & Yacoub MH (2000). Mitogenic and secretory responses of human valve interstitial cells to vasoactive agents. J Heart Valve Dis 9 , 454-458.

Hornick PI, Mason PD, Baker RJ, Hernandez-Fuentes M, Frasca L, Lombardi G, Taylor K, Weng L, Rose ML, Yacoub MH, Batchelor R, & Lechler RI (2000). Significant frequencies of T cells with indirect anti-donor specificity in heart graft recipients with chronic rejection. Circulation 101 , 2405-2410.

Jayakumar J, Suzuki K, Khan M, Smolenski RT, Farrell A, Latif N, Raisky O, Abunasra H, Sammut IA, Murtuza B, Amrani M, & Yacoub MH (2000). Gene therapy for myocardial protection: transfection of donor hearts with heat shock protein 70 gene protects cardiac function against ischemia-reperfusion injury. Circulation 102 , III302-III306.

Kalsi KK, Lawson C, McCormack A, Kochan Z, Yacoub MH, & Smolenski RT (2000). TNF-alpha reduces the activity of ecto-5'-nucleotidase in human endothelial cells. Adv Exp Med Biol 486 , 149-152.

Kalsi KK, Zych M, Slominska E, Kochan Z, Yacoub MH, & Smolenski RT (2000). Adenine incorporation in endothelial cells. Adv Exp Med Biol 486 , 145-148.

Kilner PJ, Yang GZ, Wilkes AJ, Mohiaddin RH, Firmin DN, & Yacoub MH (2000). Asymmetric redirection of flow through the heart. Nature 404 , 759-761.

Kmiec Z, Smolenski RT, Zych M, & Mysliwski A (2000). The effects of galactosamine on UTP levels in the livers of young, adult and old rats. Acta Biochim Pol 47 , 349-353.

Kochanska B, Smolenski RT, & Knap N (2000). Determination of adenine nucleotides and their metabolites in human saliva. Acta Biochim Pol 47 , 877-879.

Latif N, Khan MA, Birks E, O'Farrell A, Westbrook J, Dunn MJ, & Yacoub MH (2000). Upregulation of the Bcl-2 family of proteins in end stage heart failure. Journal of the American College of Cardiology 35 , 1769-1777.

Lawson C, McCormack AM, Moyes D, Yun S, Fabre JW, Yacoub M, & Rose ML (2000). An epithelial cell line that can stimulate alloproliferation of resting CD4+ T cells, but not after IFN-gamma stimulation. J Immunol 165 , 734-742.

Li Y, McCormack AM, Brand NJ, & Yacoub MH (2000). A strategy for inducing immune tolerance to valve endothelial cells through gene transfer. J Heart Valve Dis 9 , 439-444.

Marczin N, Royston D, & Yacoub M (2000). Pro: lung transplantation should be routinely performed with cardiopulmonary bypass. J Cardiothorac Vasc Anesth 14 , 739-745.

Marlewski M, Smolenski RT, Szolkiewicz M, Aleksandrowicz Z, Rutkowski B, & Swierczynski J (2000). Increased rate of adenine incorporation into adenine nucleotide pool in erythrocytes of patients with chronic renal failure. Nephron 86 , 281-286.

Marlewski M, Szolkiewicz M, Smolenski RT, Manitius J, Rutkowski B, & Swierczynski J (2000). Different effects of chronic renal failure on erythrocyte nucleotide concentrations in humans and rats. Nephron 84 , 92-94.

Marlewski M, Smolenski RT, Szolkiewicz M, Aleksandrowicz Z, Rutkowski B, & Swierczynski J (2000). Accelerated degradation of adenine nucleotide in erythrocytes of patients with chronic renal failure. Mol Cell Biochem 213 , 93-97.

Melina G, Rubens MB, Birks EJ, Bizzarri F, Khaghani A, & Yacoub MH (2000). A quantitative study of calcium deposition in the aortic wall following Medtronic Freestyle compared with homograft aortic root replacement. A prospective randomized trial. J Heart Valve Dis 9 , 97-103.

Merrick AF, Yacoub MH, Ho SY, & Anderson RH (2000). Anatomy of the muscular subpulmonary infundibulum with regard to the Ross procedure. Ann Thorac Surg 69 , 556-561.

Mullen AJ & Barton PJ (2000). Structural characterization of the human fast skeletal muscle troponin I gene (TNNI2). Gene 242 , 313-320.

Norman DA & Barton PJ (2000). Isolation, sequence, and chromosomal localisation of the human IkappaBR gene (NFKBIL2). Annals of Human Genetics 64 , 15-23.

Oldenburg N, Lam KM, Khan MA, Top B, Tacken NM, McKie A, Mikhail GW, Middeldorp JM, Wright A, Banner NR, & Yacoub M (2000). Evaluation of human cytomegalovirus gene expression in thoracic organ transplant recipients using nucleic acid sequence-based amplification. Transplantation 70 , 1209-1215.

Onuzo OC, Slavik Z, Franklin RC, Radley-Smith RC, & Yacoub MH (2000). Heterotopic cardiac transplantation and Batista operation. Ann Thorac Surg 70 , 285-287.

Orte C, Polak JM, Haworth SG, Yacoub MH, & Morrell NW (2000). Expression of pulmonary vascular angiotensin-converting enzyme in primary and secondary plexiform pulmonary hypertension. J Pathol 192 , 379-384.

Patel VB, Sandhu G, Corbett JM, Dunn MJ, Rodrigues LM, Griffiths JR, Wassif W, Sherwood RA, Richardson PJ, & Preedy VR (2000). A comparative investigation into the effect of chronic alcohol feeding on the myocardium of normotensive and hypertensive rats: an electrophoretic and biochemical study. Electrophoresis 21 , 2454-2462.

Patel VB, Sandhu G, Dunn MJ, Mantle D, Rodrigues LM, Griffiths JR, Wassif W, Richardson PJ, & Preedy VR (2000). Poor regression of myocardial hypertrophy following concomitant chronic alcohol ingestion and angiotensin converting enzyme (ACE) inhibition. Life Sci 67 , 1409-1421.

Rose ML (2000). Role of antibodies in transplant-associated cardiac allograft vasculopathy. Z Kardiol 89 Suppl 9 , IX/11-IX/15.

Rose ML (2000). Another way of presenting alloantigens to the immune system? Transplantation 69 , 1545-1546.

Roy A, Brand NJ, & Yacoub MH (2000). Expression of 5-hydroxytryptamine receptor subtype messenger RNA in interstitial cells from human heart valves. J Heart Valve Dis 9 , 256-260.

Roy A, Brand NJ, & Yacoub MH (2000). Molecular characterization of interstitial cells isolated from human heart valves. J Heart Valve Dis 9 , 459-464.

Sheikh S, Parhar R, Kwaasi A, Collison K, Yacoub M, Stern D, & Al Mohanna F (2000). Alpha-gal-independent dual recognition and activation of xenogeneic endothelial cells and human naive natural killer cells. Transplantation 70 , 917-928.

Slominska EM, Kalsi KK, Yacoub MH, & Smolenski RT (2000). The role of 5'-deoxy-5'-methyl thioadenosine phosphorylase in cardiac adenosine breakdown and adenine production. Adv Exp Med Biol 486 , 159-162.

Smith JD, Lawson C, Yacoub MH, & Rose ML (2000). Activation of NF-kappa B in human endothelial cells induced by monoclonal and allospecific HLA antibodies. Int Immunol 12 , 563-571.

Smolenski RT, Raisky O, Kalsi KK, Abunasra H, Jayakumar J, Suzuki K, & Yacoub MH (2000). Enhanced endogenous adenosine production and protection of the heart after transplantation. Adv Exp Med Biol 486 , 167-170.

Smolenski RT (2000). Elevation of the adenylate pool in rat cardiomyocytes by S-adenosyl-L-methionine. Acta Biochim Pol 47 , 1171-1178.

Smolenski RT, Kalsi KK, Gray CC, Zych M, Kochan Z, & Yacoub MH (2000). The effect of adenosine metabolism inhibition and nucleotide precursor supply on adenosine production in human heart endothelial cells. Adv Exp Med Biol 486 , 163-166.

Suzuki K, Brand NJ, Smolenski RT, Jayakumar J, Murtuza B, & Yacoub MH (2000). Development of a novel method for cell transplantation through the coronary artery. Circulation 102 , III359-III364.

Suzuki K, Smolenski RT, Jayakumar J, Murtuza B, Brand NJ, & Yacoub MH (2000). Heat shock treatment enhances graft cell survival in skeletal myoblast transplantation to the heart. Circulation 102 , III216-III221.

Swerdlow AJ, Higgins CD, Hunt BJ, Thomas JA, Burke MM, Crawford DH, & Yacoub MH (2000). Risk of lymphoid neoplasia after cardiothoracic transplantation. a cohort study of the relation to Epstein-Barr virus. Transplantation 69 , 897-904.

Taylor PM, Allen SP, & Yacoub MH (2000). Phenotypic and functional characterization of interstitial cells from human heart valves, pericardium and skin. J Heart Valve Dis 9 , 150-158.

Thomson JR, Machado RD, Pauciulo MW, Morgan NV, Humbert M, Elliott GC, Ward K, Yacoub M, Mikhail G, Rogers P, Newman J, Wheeler L, Higenbottam T, Gibbs JS, Egan J, Crozier A, Peacock A, Allcock R, Corris P, Loyd JE, Trembath RC, & Nichols WC (2000). Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family. J Med Genet 37 , 741-745.

Warraich RS, Pomerance A, Stanley A, Banner NR, Dunn MJ, & Yacoub MH (2000). Cardiac myosin autoantibodies and acute rejection after heart transplantation in patients with dilated cardiomyopathy. Transplantation 69 , 1609-1617.

Wharton J, Davie N, Upton PD, Yacoub MH, Polak JM, & Morrell NW (2000). Prostacyclin analogues differentially inhibit growth of distal and proximal human pulmonary artery smooth muscle cells. Circulation 102 , 3130-3136.

Wheeler MD, Rose ML, Yamashima S, Enomoto N, Seabra V, Madren J, & Thurman RG (2000). Dietary glycine blunts lung inflammatory cell influx following acute endotoxin. Am J Physiol Lung Cell Mol Physiol 279 , L390-L398.

Yan JX, Harry RA, Spibey C, & Dunn MJ (2000). Postelectrophoretic staining of proteins separated by two-dimensional gel electrophoresis using SYPRO dyes. Electrophoresis 21 , 3657-3665.

Yan JX, Wait R, Berkelman T, Harry RA, Westbrook JA, Wheeler CH, & Dunn MJ (2000). A modified silver staining protocol for visualization of proteins compatible with matrix-assisted laser desorption/ionization and electrospray ionization-mass spectrometry. Electrophoresis 21 , 3666-3672.

Yun S, Rose ML, & Fabre JW (2000). The induction of major histocompatibility complex class II expression is sufficient for the direct activation of human CD4+ T cells by porcine vascular endothelial cells. Transplantation 69 , 940-944.