Publications 2001

Abunasra HJ, Smolenski RT, Morrison K, Yap J, Sheppard MN, O'Brien T, Suzuki K, Jayakumar J, & Yacoub MH (2001). Efficacy of adenoviral gene transfer with manganese superoxide dismutase and endothelial nitric oxide synthase in reducing ischemia and reperfusion injury. Eur J Cardiothorac Surg 20 , 153-158.

Al Ruzzeh S, George S, Yacoub M, & Amrani M (2001). The clinical outcome of off-pump coronary artery bypass surgery in the elderly patients. Eur J Cardiothorac Surg 20 , 1152-1156.

Anyanwu AC, Saeed I, Bustami M, Ilsley C, Yacoub MH, & Amrani M (2001). Does routine use of the radial artery increase complexity or morbidity of coronary bypass surgery? Ann Thorac Surg 71 , 555-559.

Batten P, McCormack AM, Rose ML, & Yacoub MH (2001). Valve interstitial cells induce donor-specific T-cell anergy. J Thorac Cardiovasc Surg 122 , 129-135.

Birks EJ, Latif N, Owen V, Bowles C, Felkin LE, Mullen AJ, Khaghani A, Barton PJ, Polak JM, Pepper JR, Banner NR, & Yacoub MH (2001). Quantitative myocardial cytokine expression and activation of the apoptotic pathway in patients who require left ventricular assist devices. Circulation 104 , I233-I240.

Birks EJ, Burton PB, Owen VJ, Latif N, Nyawo B, & Yacoub MH (2001). Molecular and cellular mechanisms of donor heart dysfunction. Transplant Proc 33 , 2749-2751.

Birks EJ, Khaghani A, Bowles C, Hunt D, Pepper JR, Banner NR, & Yacoub MH (2001). Serum cytokines in left ventricular assist device candidates. Transplant Proc 33 , 1974-1975.

Boateng SY, Naqvi RU, Koban MU, Yacoub MH, MacLeod KT, & Boheler KR (2001). Low-dose ramipril treatment improves relaxation and calcium cycling after established cardiac hypertrophy. Am J Physiol Heart Circ Physiol 280 , H1029-H1038.

Borozdenkova S, Smith J, Marshall S, Yacoub M, & Rose M (2001). Identification of ICAM-1 polymorphism that is associated with protection from transplant associated vasculopathy after cardiac transplantation. Hum Immunol 62 , 247-255.

Carr-White GS, Kilner PJ, Hon JK, Rutledge T, Edwards S, Burman ED, Pennell DJ, & Yacoub MH (2001). Incidence, location, pathology, and significance of pulmonary homograft stenosis after the Ross operation. Circulation 104 , I16-I20.

Chester AH, Misfeld M, Sievers HH, & Yacoub MH (2001). Influence of 5-hydroxytryptamine on aortic valve competence in vitro. J Heart Valve Dis 10 , 822-825.

Davidson SJ, Burman JF, Rutherford LC, Keogh BF, & Yacoub MH (2001). High molecular weight kininogen deficiency: a patient who underwent cardiac surgery. Thromb Haemost 85 , 195-197.

Dellow KA, Bhavsar PK, Brand NJ, & Barton PJ (2001). Identification of novel, cardiac-restricted transcription factors binding to a CACC-box within the human cardiac troponin I promoter. Cardiovasc Res 50 , 24-33.

Dubrey SW, Burke MM, Khaghani A, Hawkins PN, Yacoub MH, & Banner NR (2001). Long term results of heart transplantation in patients with amyloid heart disease. Heart 85 , 202-207.

Dupont E, Matsushita T, Kaba RA, Vozzi C, Coppen SR, Khan N, Kaprielian R, Yacoub MH, & Severs NJ (2001). Altered connexin expression in human congestive heart failure. J Mol Cell Cardiol 33 , 359-371.

Edgar AJ, Birks EJ, Yacoub MH, & Polak JM (2001). Cloning of dexamethasone-induced transcript: a novel glucocorticoid-induced gene that is upregulated in emphysema. Am J Respir Cell Mol Biol 25 , 119-124.

El Oakley RM, Ooi OC, Bongso A, & Yacoub MH (2001). Myocyte transplantation for myocardial repair: a few good cells can mend a broken heart. Ann Thorac Surg 71 , 1724-1733.

Ensminger SM, Spriewald BM, Sorensen HV, Witzke O, Flashman EG, Bushell A, Morris PJ, Rose ML, Rahemtulla A, & Wood KJ (2001). Critical role for IL-4 in the development of transplant arteriosclerosis in the absence of CD40-CD154 costimulation. J Immunol 167 , 532-541.

Finney PA, Donnelly LE, Belvisi MG, Chuang TT, Birrell M, Harris A, Mak JC, Scorer C, Barnes PJ, Adcock IM, & Giembycz MA (2001). Chronic systemic administration of salmeterol to rats promotes pulmonary beta(2)-adrenoceptor desensitization and down-regulation of G(s alpha). Br J Pharmacol 132 , 1261-1270.

Forrest MR, Chester AH, & Royston D (2001). The effects of diaspirin cross-linked hemoglobin on the tone of human saphenous vein. Anesth Analg 92 , 324-328.

Fox AJ, Patel HJ, Barnes PJ, & Belvisi MG (2001). Release of nerve growth factor by human pulmonary epithelial cells: role in airway inflammatory diseases. Eur J Pharmacol 424 , 159-162.

Frati G, Frati P, Muzzi L, Oricchio G, Papalia U, & Yacoub MH (2001). Medical and ethical issues in xenotransplantation: the opinion of the public, patients, and transplant candidates in Italy. Transplant Proc 33 , 1884-1885.

Goodwin AT, Smolenski RT, Gray CC, Jayakumar J, Amrani M, & Yacoub MH (2001). Role of endogenous endothelin on coronary reflow after cardioplegic arrest. J Thorac Cardiovasc Surg 122 , 1167-1173.

Goodwin AT & Yacoub MH (2001). Role of endogenous endothelin on coronary flow in health and disease. Coron Artery Dis 12 , 517-525.

Gray CC, Amrani M, Smolenski RT, Nakamura K, & Yacoub MH (2001). Cold cardioplegic arrest enhances heat shock protein 70 in the heat-shocked rat heart. J Thorac Cardiovasc Surg 121 , 1130-1136.

Haddad EB, Birrell M, McCluskie K, Ling A, Webber SE, Foster ML, & Belvisi MG (2001). Role of p38 MAP kinase in LPS-induced airway inflammation in the rat. Br J Pharmacol 132 , 1715-1724.

Hele DJ, Birrell MA, Webber SE, Foster ML, & Belvisi MG (2001). Mediator involvement in antigen-induced bronchospasm and microvascular leakage in the airways of ovalbumin sensitized Brown Norway rats. Br J Pharmacol 132 , 481-488.

Hele DJ, Yacoub MH, & Belvisi MG (2001). The heterotopic tracheal allograft as an animal model of obliterative bronchiolitis. Respir Res 2 , 169-183.

Hon JK, Steendijk P, Petrou M, Wong K, & Yacoub MH (2001). Influence of clenbuterol treatment during six weeks of chronic right ventricular pressure overload as studied with pressure-volume analysis. J Thorac Cardiovasc Surg 122 , 767-774.

Hon JK, Steendijk P, Khan H, Wong K, & Yacoub M (2001). Acute effects of pulmonary artery banding in sheep on right ventricle pressure-volume relations: relevance to the arterial switch operation. Acta Physiol Scand 172 , 97-106.

Jayakumar J, Suzuki K, Sammut IA, Smolenski RT, Khan M, Latif N, Abunasra H, Murtuza B, Amrani M, & Yacoub MH (2001). Heat shock protein 70 gene transfection protects mitochondrial and ventricular function against ischemia-reperfusion injury. Circulation 104 , I303-I307.

Jiang L, Tsubakihara M, Heinke MY, Yao M, Dunn MJ, Phillips W, Dos Remedios CG, & Nosworthy NJ (2001). Heart failure and apoptosis: electrophoretic methods support data from micro- and macro-arrays. A critical review of genomics and proteomics. Proteomics 1 , 1481-1488.

Jurcevic S, Ainsworth ME, Pomerance A, Smith JD, Robinson DR, Dunn MJ, Yacoub MH, & Rose ML (2001). Antivimentin antibodies are an independent predictor of transplant-associated coronary artery disease after cardiac transplantation. Transplantation 71 , 886-892.

Kaba RA, Coppen SR, Dupont E, Skepper JN, Elneil S, Haw MP, Pepper JR, Yacoub MH, Rothery S, & Severs NJ (2001). Comparison of connexin 43, 40 and 45 expression patterns in the developing human and mouse hearts. Cell Commun Adhes 8 , 339-343.

Koban MU, Brugh SA, Riordon DR, Dellow KA, Yang HT, Tweedie D, & Boheler KR (2001). A distant upstream region of the rat multipartite Na(+)-Ca(2+) exchanger NCX1 gene promoter is sufficient to confer cardiac-specific expression. Mech Dev 109 , 267-279.

Lango R, Smolenski RT, Narkiewicz M, Suchorzewska J, & Lysiak-Szydlowska W (2001). Influence of L-carnitine and its derivatives on myocardial metabolism and function in ischemic heart disease and during cardiopulmonary bypass. Cardiovasc Res 51 , 21-29.

Lawson C, Ainsworth ME, McCormack AM, Yacoub M, & Rose ML (2001). Effects of cross-linking ICAM-1 on the surface of human vascular smooth muscle cells: induction of VCAM-1 but no proliferation. Cardiovasc Res 50 , 547-555.

Lazzeri N, Belvisi MG, Patel HJ, Chung KF, Yacoub MH, & Mitchell JA (2001). RANTES release by human airway smooth muscle: effects of prostaglandin E(2) and fenoterol. Eur J Pharmacol 433 , 231-235.

Lazzeri N, Belvisi MG, Patel HJ, Yacoub MH, Fan CK, & Mitchell JA (2001). Effects of prostaglandin E2 and cAMP elevating drugs on GM-CSF release by cultured human airway smooth muscle cells. Relevance to asthma therapy. Am J Respir Cell Mol Biol 24 , 44-48.

Leung KY, Wait R, Welson SY, Yan JX, Abraham DJ, Black CM, Pearson JD, & Dunn MJ (2001). A reference map of human lung MRC-5 fibroblast proteins using immobilized pH gradient-isoelectric focusing-based two-dimensional electrophoresis. Proteomics 1 , 787-794.

Linke AT, Marchant B, Marsh P, Frampton G, Murphy J, & Rose ML (2001). Screening of a HUVEC cDNA library with transplant-associated coronary artery disease sera identifies RPL7 as a candidate autoantigen associated with this disease. Clin Exp Immunol 126 , 173-179.

Machado RD, Pauciulo MW, Thomson JR, Lane KB, Morgan NV, Wheeler L, Phillips JA, III, Newman J, Williams D, Galie N, Manes A, McNeil K, Yacoub M, Mikhail G, Rogers P, Corris P, Humbert M, Donnai D, Martensson G, Tranebjaerg L, Loyd JE, Trembath RC, & Nichols WC (2001). BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension. Am J Hum Genet 68 , 92-102.

Marcus NJ, Breen JB, Yacoub MH, & Banner NR (2001). A randomised controlled trial of antihypertensive treatment with valsartan after heart transplantation. J Heart Lung Transplant 20 , 246.

McDouall RM, Farrar MW, Khan S, Yacoub MH, & Allen SP (2001). Unique sensitivities to cytokine regulated expression of adhesion molecules in human heart-derived endothelial cells. Endothelium 8 , 25-40.

McGregor E, Kempster L, Wait R, Welson SY, Gosling M, Dunn MJ, & Powel JT (2001). Identification and mapping of human saphenous vein medial smooth muscle proteins by two-dimensional polyacrylamide gel electrophoresis. Proteomics 1 , 1405-1414.

Melina G, Rubens MB, Amrani M, Khaghani A, & Yacoub MH (2001). Electron beam tomography for cusp calcification in homograft versus Freestyle xenografts. Ann Thorac Surg 71 , S368-S370.

Mikhail GW, Gibbs JS, & Yacoub MH (2001). Pulmonary and systemic arterial pressure changes during syncope in primary pulmonary hypertension. Circulation 104 , 1326-1327.

Newell H, Smith J, Pomerance A, Yacoub M, & Rose M (2001). The effect of interleukin-6 gene polymorphisms on the outcome of cardiac transplantation. J Heart Lung Transplant 20 , 213-214.

Noutsias M, Fechner H, de Jonge H, Wang X, Dekkers D, Houtsmuller AB, Pauschinger M, Bergelson J, Warraich R, Yacoub M, Hetzer R, Lamers J, Schultheiss HP, & Poller W (2001). Human coxsackie-adenovirus receptor is colocalized with integrins alpha(v)beta(3) and alpha(v)beta(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: implications for cardiotropic viral infections. Circulation 104 , 275-280.

Owen VJ, Burton PB, Mullen AJ, Birks EJ, Barton PJ, & Yacoub MH (2001). Expression of RGS3, RGS4 and Gi alpha 2 in acutely failing donor hearts and end-stage heart failure. European Heart Journal 22 , 1015-1020.

Raisky O, Morrison KJ, Obadia JF, McGregor J, Yacoub MH, & Rose ML (2001). Acute rejection and cardiac graft vasculopathy in the absence of donor-derived ICAM-1 or P-selectin. J Heart Lung Transplant 20 , 340-349.

Reichart B, Meiser B, Vigano M, Rinaldi M, Yacoub M, Banner NR, Gandjbakhch I, Dorent R, Hetzer R, & Hummel M (2001). European multicenter tacrolimus heart pilot study: three year follow-up. J Heart Lung Transplant 20 , 249-250.

Rose ML (2001). Anti-vimentin antibodies are an independent predictor of transplant-associated coronary artery disease following cardiac transplantation. Ital Heart J 2 Suppl 3 , 23S-25S.

Rose ML, Smith JD, & Lawson C (2001). Antibody formation and its impact on long-term graft outcome. Transplant Proc 33 , 2411-2413.

Saeed I, Anyanwu AC, Yacoub MH, & Amrani M (2001). Subjective patient outcomes following coronary artery bypass using the radial artery: results of a cross-sectional survey of harvest site complications and quality of life. Eur J Cardiothorac Surg 20 , 1142-1146.

Sammut IA, Jayakumar J, Latif N, Rothery S, Severs NJ, Smolenski RT, Bates TE, & Yacoub MH (2001). Heat stress contributes to the enhancement of cardiac mitochondrial complex activity. Am J Pathol 158 , 1821-1831.

Santalucia T, Moreno H, Palacin M, Yacoub MH, Brand NJ, & Zorzano A (2001). A novel functional co-operation between MyoD, MEF2 and TRalpha1 is sufficient for the induction of GLUT4 gene transcription. J Mol Biol 314 , 195-204.

Smolenski R, Kochan Z, Karbowska J, Slominska E, Forni M, Kalsi K, Bacci ML, Lavitrano M, & Yacoub MH (2001). Low expression of ecto-5'-nucleotidase in the pig heart - a potential barrier to xenotransplantation. J Heart Lung Transplant 20 , 214-215.

Smolenski RT, Raisky O, Slominska EM, Abunasra H, Kalsi KK, Jayakumar J, Suzuki K, & Yacoub MH (2001). Protection from reperfusion injury after cardiac transplantation by inhibition of adenosine metabolism and nucleotide precursor supply. Circulation 104 , I246-I252.

Smolenski RT, Amrani M, Jayakumar J, Jagodzinski P, Gray CC, Goodwin AT, Sammut IA, & Yacoub MH (2001). Pyruvate/dichloroacetate supply during reperfusion accelerates recovery of cardiac energetics and improves mechanical function following cardioplegic arrest. Eur J Cardiothorac Surg 19 , 865-872.

Smolenski RT, Raisky O, Zych M, Kochan Z, Kalsi KK, Abunasra H, Jayakumar J, Suzuki K, & Yacoub MH (2001). Enhanced endogenous adenosine protects from reperfusion injury after heart transplantation. Transplant Proc 33 , 924-925.

Spicuzza L, Belvisi MG, Birrell MA, Barnes PJ, Hele DJ, & Giembycz MA (2001). Evidence that the anti-spasmogenic effect of the beta-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase. Br J Pharmacol 133 , 1201-1212.

Spicuzza L, Barnes PJ, Di Maria GU, & Belvisi MG (2001). Effect of 8-iso-prostaglandin F(2 alpha) on acetylcholine release from parasympathetic nerves in guinea pig airways. Eur J Pharmacol 416 , 231-234.

Suzuki K, Murtuza B, Suzuki N, Smolenski RT, & Yacoub MH (2001). Intracoronary infusion of skeletal myoblasts improves cardiac function in doxorubicin-induced heart failure. Circulation 104 , I213-I217.

Suzuki K, Murtuza B, Smolenski RT, Sammut IA, Suzuki N, Kaneda Y, & Yacoub MH (2001). Overexpression of interleukin-1 receptor antagonist provides cardioprotection against ischemia-reperfusion injury associated with reduction in apoptosis. Circulation 104 , I308-I3I3.

Suzuki K, Brand NJ, Allen S, Khan MA, Farrell AO, Murtuza B, Oakley RE, & Yacoub MH (2001). Overexpression of connexin 43 in skeletal myoblasts: Relevance to cell transplantation to the heart. J Thorac Cardiovasc Surg 122 , 759-766.

Suzuki K, Murtuza B, Smolenski RT, Sammut IA, Suzuki N, Kaneda Y, & Yacoub MH (2001). Cell transplantation for the treatment of acute myocardial infarction using vascular endothelial growth factor-expressing skeletal myoblasts. Circulation 104 , I207-I212.

Swierczynski J, Slominska E, Smolenski RT, & Mayer D (2001). Increase in NAD but not ATP and GTP concentrations in rat liver by dehydroepiandrosterone feeding. Pol J Pharmacol 53 , 125-130.

Thomas PS, Kasahara H, Edmonson AM, Izumo S, Yacoub MH, Barton PJ, & Gourdie RG (2001). Elevated expression of Nkx-2.5 in developing myocardial conduction cells. Anat Rec 263 , 307-313.

Thomson J, Machado R, Pauciulo M, Morgan N, Yacoub M, Corris P, McNeil K, Loyd J, Nichols W, & Trembath R (2001). Familial and sporadic primary pulmonary hypertension is caused by BMPR2 gene mutations resulting in haploinsufficiency of the bone morphogenetic protein tuype II receptor. J Heart Lung Transplant 20 , 149.

Tuder RM, Chacon M, Alger L, Wang J, Taraseviciene-Stewart L, Kasahara Y, Cool CD, Bishop AE, Geraci M, Semenza GL, Yacoub M, Polak JM, & Voelkel NF (2001). Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis. J Pathol 195 , 367-374.

Upton PD, Wharton J, Coppock H, Davie N, Yang X, Yacoub MH, Ghatei MA, Polak JM, Bloom SR, Smith DM, & Morrell NW (2001). Adrenomedullin expression and growth inhibitory effects in distinct pulmonary artery smooth muscle cell subpopulations. Am J Respir Cell Mol Biol 24 , 170-178.

Varghese D, Yacoub MH, Trimlett R, & Amrani M (2001). Outcome of non-elective coronary artery bypass grafting without cardio-pulmonary bypass. Eur J Cardiothorac Surg 19 , 245-248.

Westbrook JA, Yan JX, Wait R, & Dunn MJ (2001). A combined radiolabelling and silver staining technique for improved visualisation, localisation, and identification of proteins separated by two-dimensional gel electrophoresis. Proteomics 1 , 370-376.

Westbrook JA, Yan JX, Wait R, Welson SY, & Dunn MJ (2001). Zooming-in on the proteome: very narrow-range immobilised pH gradients reveal more protein species and isoforms. Electrophoresis 22 , 2865-2871.

Wray J, Long T, Radley-Smith R, & Yacoub M (2001). Returning to school after heart or heart-lung transplantation: how well do children adjust? Transplantation 72 , 100-106.

Yacoub M (2001). Off-pump coronary bypass surgery: in search of an identity. Circulation 104 , 1743-1745.

Yacoub MH, Tansley P, Birks EJ, Banner NR, Khaghani A, Bowles C, Banner WR, & Khaghan A (2001). A novel combination therapy to reverse end-stage heart failure. Transplant Proc 33 , 2762-2764.

Yacoub MH (2001). A novel strategy to maximize the efficacy of left ventricular assist devices as a bridge to recovery. European Heart Journal 22 , 534-540.

Yan JX, Harry RA, Wait R, Welson SY, Emery PW, Preedy VR, & Dunn MJ (2001). Separation and identification of rat skeletal muscle proteins using two-dimensional gel electrophoresis and mass spectrometry. Proteomics 1 , 424-434.