The aim of the Vascular Biology group is to understand mechanisms that regulate vascular tone and contribute to vascular protection. In the past we have examined the effect of a number of different vasoactive mediators on human vascular tone in vitro. Studies have included 5-HT receptors, nitric oxide, intestinal peptides, leukotrienes, endothelin, and the renin-angiotensin system. Currently our work centres on the genetic variation in endothelin receptor function, the role of bone morphogenetic proteins and the action of cardiac peptides in vascular protection. We have also developed an interest in examining how the function of the aortic valve may also be regulated by receptor mechanisms.

Recent publications

Isolated organ baths used for in vitro assessment of Vascular Function